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KMID : 0388220110180020118
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Journal of the Korean Rheumatism Association
2011 Volume.18 No. 2 p.118 ~ p.121
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Efficacy of Imatinib Mesylate Treatment for a Patient with Rheumatoid Arthritis and Who Developed Chronic Myelogenous Leukemia
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Jeon Hye-Kyung
Park Young-Eun
Kim Sung-Il
Park Seong-Hu
Back Seung-Hoon
Lee Joung-Wook
Ha Dong-Woo
Lee Hye-Won
Chung Joo-Seop
Lee Seung-Hee
Lee Eun-Yup
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Abstract
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Rheumatoid arthritis is associated with an increased risk of hematological malignancy as a result of the RA itself or its treatment. We report here on an unusual case of a 55-year-old female with long-standing rheumatoid arthritis and who was treated with low dose methotrexate and hydrochloroquine. She was diagnosed with chronic myelogenous leukemia that manifested with severe thrombocytosis and basophilia, and this was treated with imatinib mesylate. After 6 months, she achieved a complete cytogenetic response of the CML and a complete resolution of all the RA symptoms without DMARDs.
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KEYWORD
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Rheumatoid arthritis, Chronic myelogenous leukemia, Imatinib mesylate
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